From folding intermediates to candidates molecules

Sibylla Biotech scientists have designed and built an ad-hoc virtual screening workflow to assist and accelerate the identification of potential small-molecule binders of protein folding intermediates. The chemical libraries available for hit identification include a database of approved/experimental drugs and a diverse collection of approximately 3.2 million drug-like compounds (in-stock commercially available and make-on-demand compounds). The latter library has been carefully designed to cover an adequate chemical space with the highest level of diversity, and to include only medchem friendly compounds (no PAINS). Sibylla Biotech also applies a wide range of advanced computational approaches to speed up the hit-to-lead optimization phase

  • Protein folding simulation

    Protein folding simulation
    Alpha-1 antitripsin

  • Application to misfolding

    Application to misfolding
    Prion protein
    Atomistic simulation of the interconversion of a cellular prion protein into a pathogenic aggregate of misfolded prion proteins
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news

April 2020
New structural target against COVID-19
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April 2020
Paper Online
The scientific paper about PPI-FIT technology and its first validation is now online!
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January 2020
A documentary on Sibylla Biotech broadcasted on TV
"4.0 La fabbrica del futuro"
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January 2020
New team member!
Computer scientist Luca Terruzzi hired in the scientific staff

November 2019
Interview to Prof. Maria Letizia Barreca, co-founder
Watch the interview in italian
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November 2019
New team member!
Head of wet laboratory dr. Tania Massignan hired in the scientific staff

October 2019
Interview to Prof. Emiliano Biasini, co-founder
Watch the interview in italian
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October 2019
Vertis Venture 3 Tech Transfer finances our research
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October 2019
Press release
Watch the press release in italian
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