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Fold the future

Sibylla is a preclinical stage company focused on developing small molecule degraders with a novel Mechanism of Action to find new therapeutics for unmet medical needs.

Our platform is powered by computer simulations and AI methods, which enables the discovery and development of compounds that induce the degradation of a target protein by interfering with its folding pathway.

By exploiting this new paradigm that we named “Pharmacological Protein Inactivation by Folding Intermediates Targeting” (PPI-FIT), Sibylla can identify and develop small molecules acting on targets involved in different types of diseases. Indeed, PPI-FIT is applicable to any therapeutic area.

 

 

 

PPI-FIT
The Concept

Protein Folding Simulations

Oneiros
AI Platform

Drug Discovery & Development Platform

Sibylla Biotech and MD Anderson Announce Strategic Collaboration to Discover and Develop Small-Molecule Protein Degraders

Sibylla’s PPI-FIT technology joins with MD Anderson’s drug development resources and expertise to create protein folding interfering degraders as cancer therapies HOUSTON and MILAN, June 12, 2024 – Sibylla Biotech and The University of Texas MD Anderson Cancer Center...

Sibylla Biotech Enters a Strategic Drug Discovery Collaboration with Ono Pharmaceutical in Central Nervous System Disorders

Sibylla Biotech Enters a Strategic Drug Discovery Collaboration with Ono Pharmaceutical in Central Nervous System Disorders Milan, Italy, March 14, 2024 – Sibylla Biotech announced today a drug discovery collaboration with Ono Pharmaceutical Co., Ltd. (TSE: 4528) that...

Sibylla Biotech Appoints Dominique Bridon as Executive Chairman of the Board

Sibylla Biotech Appoints Dominique Bridon as Executive Chairman of the Board Milan, Italy, September 28, 2023 – Sibylla Biotech today announces the appointment of Dominique Bridon, Ph.D., as Executive Chairman of its Board of Directors. Dr. Bridon brings more than 30...

Sibylla Biotech Raises €23 Million Series A to Advance Protein Degradation by Folding Interference Pipeline and Expand Technology Platform

Sibylla Biotech Raises €23 Million Series A to Advance Protein Degradation by Folding Interference Pipeline and Expand Technology Platform Verona, Italy, October 4, 2022 – Sibylla Biotech today announced the successful close of its €23 million Series A financing round...

Giovanni Spagnolli appointed as CTO

Giovanni Spagnolli appointed as CTO of Sibylla Biotech

Sibylla Biotech selected by Nature among the eight best start-ups in the world in the life-science sector

Sibylla Biotech selected by Nature among the eight best start-ups in the world in the life-science sector Sibylla Biotech, a spin-off of INFN, the University of Trento, and the University of Perugia, has been selected, the only Italian company, as a finalist of the...

Sibylla Biotech Announces Drug Discovery Agreement with Takeda

Sibylla Biotech will use its Drug Discovery platform to modulate the activity of targets supplied by Takeda. The Italian startup company will partner its innovative PPI-FIT Drug Discovery platform with Takeda to generate novel compounds designed to modulate the...

The scientific paper about PPI-FIT technology

Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution.

New structural target against COVID-19

A new structural target for drug development against COVID-19 has been unveiled today by Sibylla Biotech in collaboration with the Italian National Institute of Nuclear Physics (INFN), the University of Trento and University of Perugia.

A documentary on Sibylla Biotech broadcasted on TV

A documentary on Sibylla Biotech broadcasted on TV 4.0 La fabbrica del futuro