Folding recostruction
Computational drug discovery
Experimental validation

At Sibylla Biotech we enjoy scientific challenges
and we believe in pursuing original ideas.

UPDATE: Our research led to the discovery of a new structural target for the ACE-2 protein. Read more. 

This commitment is reflected in our research. We have developed an innovative protocol for drug discovery called PPI-FIT that allows us to identify drug candidates capable of suppressing the expression of target proteins.

Scientists at Sibylla Biotech exploit the full potential of the PPI-FIT technology by applying a unique, cross-disciplinary workflow ranging from the reconstruction of folding pathways using Sibylla’s exclusive computational technology to the identification of drug candidates by mean of medicinal chemistry schemes, to the full characterization and testing of the therapeutic potentials of these compounds in the biological laboratory, by employing relevant experimental models of disease. In this framework, Sibylla’s research covers a wide area of the typical drug discovery pipeline, from the initial step of target identification up to the pre-clinical development and validation of potential new drugs.

Our clients take advantage of our multidisciplinary expertise and innovative technology for their drug discovery needs.
Sibylla Biotech can provide:
>  3D structures of the folding intermediates
>  identification and modeling of druggable sites exclusively present on such protein conformations.

This information can be used for virtual screening in order to identify small molecules specifically able to bind and stabilize the intermediates, thus interfering on the folding process. Experimental hit validation can be provided by a panel of in vitro assays.
We can also implement customized solutions from the validated hits to follow on to optimized lead identification and pre-clinical candidates selection.

news

April 2020
New structural target against COVID-19
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April 2020
Paper Online
The scientific paper about PPI-FIT technology and its first validation is now online!
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January 2020
A documentary on Sibylla Biotech broadcasted on TV
"4.0 La fabbrica del futuro"
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January 2020
New team member!
Computer scientist Luca Terruzzi hired in the scientific staff

November 2019
Interview to Prof. Maria Letizia Barreca, co-founder
Watch the interview in italian
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November 2019
New team member!
Head of wet laboratory dr. Tania Massignan hired in the scientific staff

October 2019
Interview to Prof. Emiliano Biasini, co-founder
Watch the interview in italian
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October 2019
Vertis Venture 3 Tech Transfer finances our research
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October 2019
Press release
Watch the press release in italian
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